The Jesse Pointing a Gun meme refers to a GIF of the Breaking Bad character Jesse Pinkman (played by Aaron Paul) pointing a gun directly at the camera. In the final scene of episode 13th of 3rd season, Jesse is ordered by Walter to kill the character Gale. The episode ends with a shot of a teary-eyed Jesse pointing a gun at the camera and pulling the trigger, which is the scene this GIF is from.